Indole-2-carboxylic acid methyl ester

Indole-2-carboxylic acid methyl ester is a carbazole that can be synthesized from indole and hydrogen chloride. It has been shown to inhibit the production of β-amyloid, an important factor in the pathogenesis of Alzheimer’s disease. Indole-2-carboxylic acid methyl ester has also been shown to have inhibitory effects on ion-exchange, melatonin synthesis, and yields of aziridines. The affinity of indole-2-carboxylic acid methyl ester for aldehydes was found to be very high. It is also able to cross the blood brain barrier into the brain and has been shown to be effective against pancreatic cancer cells in vitro.